Varicella-Zoster Virus Open Reading Frame 10 Is a Virulence Determinant in Skin Cells but Not in T Cells In Vivo

The open reading frame 10 (ORF10) of varicella-zoster virus (VZV) encodes a tegument protein that enhances transactivation of VZV genes and has homology to herpes simplex virus type 1 (HSV-1) VP16. While VP16 is essential for HSV replication, ORF10 is dispensable for vaccine OKA (VOKA) growth in vit...

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Detalhes bibliográficos
Main Authors: Che, Xibing, Zerboni, Leigh, Sommer, Marvin H., Arvin, Ann M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440391/
https://ncbi.nlm.nih.gov/pubmed/16537591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3238-3248.2006
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