Downregulation of Varicella-Zoster Virus (VZV) Immediate-Early ORF62 Transcription by VZV ORF63 Correlates with Virus Replication In Vitro and with Latency

Varicella-zoster virus (VZV) open reading frame 63 (ORF63) protein is expressed during latency in human sensory ganglia. Deletion of ORF63 impairs virus replication in cell culture and establishment of latency in cotton rats. We found that cells infected with a VZV ORF63 deletion mutant yielded low...

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Autors principals: Hoover, Susan E., Cohrs, Randall J., Rangel, Zoila G., Gilden, Donald H., Munson, Peter, Cohen, Jeffrey I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440367/
https://ncbi.nlm.nih.gov/pubmed/16537613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3459-3468.2006
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