Production of a Doubly Chiral Compound, (4R,6R)-4-Hydroxy-2,2,6-Trimethylcyclohexanone, by Two-Step Enzymatic Asymmetric Reduction

A practical enzymatic synthesis of a doubly chiral key compound, (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, starting from the readily available 2,6,6-trimethyl-2-cyclohexen-1,4-dione is described. Chirality is first introduced at the C-6 position by a stereoselective enzymatic hydrogenation of...

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Pubblicato in:	Appl Environ Microbiol
Autori principali:	Wada, Masaru, Yoshizumi, Ayumi, Noda, Yumiko, Kataoka, Michihiko, Shimizu, Sakayu, Takagi, Hiroshi, Nakamori, Shigeru
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Physiology and Biotechnology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC143664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12571014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.2.933-937.2003
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