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Structural mechanism for sterol sensing and transport by OSBP-related proteins
The oxysterol binding protein (OSBP)-related proteins (ORPs) are conserved from yeast to man 1,2 and are implicated in regulation of sterol pathways 3,4 and in signal transduction 5. The structure of the full-length yeast ORP Osh4 was determined at 1.5–1.9 Å resolution in complexes with ergosterol,...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1431608/ https://ncbi.nlm.nih.gov/pubmed/16136145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature03923 |
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