Murine Cathepsin F Deficiency Causes Neuronal Lipofuscinosis and Late-Onset Neurological Disease

Cathepsin F (cat F) is a widely expressed lysosomal cysteine protease whose in vivo role is unknown. To address this issue, mice deficient in cat F were generated via homologous recombination. Although cat F(−/−) mice appeared healthy and reproduced normally, they developed progressive hind leg weak...

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Bibliographic Details
Main Authors: Tang, Chi-Hui, Lee, Je-Wook, Galvez, Michael G., Robillard, Liliane, Mole, Sara E., Chapman, Harold A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430281/
https://ncbi.nlm.nih.gov/pubmed/16508006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2309-2316.2006
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