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Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency

1 A single oral dose of 500 mg diflunisal was administered to control subjects and patients with varying degrees of renal insufficiency to estimate the disposition kinetics of this drug. 2 Diflunisal and the sum of its ester and ether glucuronides conjugates were measured fluorimetrically. 3 In norm...

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Autori principali: Verbeeck, R., Tjandramaga, T. B., Mullie, A., Verbesselt, R., Verberckmoes, R., De Schepper, P. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1979
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1429486/
https://ncbi.nlm.nih.gov/pubmed/427004
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