Identification of hydrallazine and hydrallazine hydrazone metabolites in human body fluids and quantitative in vitro comparisons of their smooth muscle relaxant activity.

1 Serum and urine from hypertensive subjects on chronic oral hydrallazine therapy were studied using gas chromatographic/mass spectrometry techniques. 2 Metabolites resulting from acetylation, hydrolysis and conjugation reactions were detected. The acetone, pyruvate and alpha-ketoglutarate hydrazone...

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Detalhes bibliográficos
Main Authors: Haegele, K D, McLean, A J, du Souich, P, Barron, K, Laquer, J, McNay, J L, Carrier, O
Formato: Artigo
Idioma:Inglês
Publicado em: 1978
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1429372/
https://ncbi.nlm.nih.gov/pubmed/656292
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