Pharmacokinetics of Tenofovir Disoproxil Fumarate and Ritonavir-Boosted Saquinavir Mesylate Administered Alone or in Combination at Steady State

A phase I study was conducted to formally evaluate the steady-state pharmacokinetics (PK) of tenofovir disoproxil fumarate (TDF) and ritonavir (RTV)-boosted saquinavir mesylate (SQV) when coadministered in healthy volunteers. Forty subjects received multiple doses of TDF (300 mg, once daily) and SQV...

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Detalhes bibliográficos
Main Authors: Chittick, Gregory E., Zong, Jian, Blum, M. Robert, Sorbel, Jeffrey J., Begley, John A., Adda, Nathalie, Kearney, Brian P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426992/
https://ncbi.nlm.nih.gov/pubmed/16569845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1304-1310.2006
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