Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells

PTX (Paclitaxel®) is an antimitotic agent used in the treatment of a number of major solid tumours, particularly in breast and ovarian cancer. This study was undertaken to gain insight into the molecular alterations producing PTX resistance in ovarian cancer. PTX treatment is able to induce apoptosi...

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Autores principales: Prinetti, Alessandro, Millimaggi, Danilo, D'Ascenzo, Sandra, Clarkson, Matilda, Bettiga, Arianna, Chigorno, Vanna, Sonnino, Sandro, Pavan, Antonio, Dolo, Vincenza
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2006
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1422777/
https://ncbi.nlm.nih.gov/pubmed/16356169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051184
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