HTLV-1 propels untransformed CD4(+) lymphocytes into the cell cycle while protecting CD8(+) cells from death

Human T cell leukemia virus type 1 (HTLV-1) infects both CD4(+) and CD8(+) lymphocytes, yet it induces adult T cell leukemia/lymphoma (ATLL) that is regularly of the CD4(+) phenotype. Here we show that in vivo infected CD4(+) and CD8(+) T cells displayed similar patterns of clonal expansion in carri...

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Detalhes bibliográficos
Main Authors: Sibon, David, Gabet, Anne-Sophie, Zandecki, Marc, Pinatel, Christiane, Thête, Julien, Delfau-Larue, Marie-Hélène, Rabaaoui, Samira, Gessain, Antoine, Gout, Olivier, Jacobson, Steven, Mortreux, Franck, Wattel, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1421359/
https://ncbi.nlm.nih.gov/pubmed/16585963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27198
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