Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752, NCT00260325]

BACKGROUND: Induction of the COX-2 isoenzyme appears to play a major role in the genesis of central sensitization after nociceptive stimulation. This study aimed to investigate the efficacy of a single, oral dose of the specific COX-2 inhibitor-valdecoxib in attenuating the central sensitization – i...

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Hlavní autoři: Burns, David, Hill, Lindsay, Essandoh, Michael, Jarzembowski, Tomasz M, Schuler, H Gregg, Janicki, Piotr K
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2006
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1420273/
https://ncbi.nlm.nih.gov/pubmed/16529650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2253-6-3
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