Mutation of Phosphotransacetylase but Not Isocitrate Lyase Reduces the Virulence of Salmonella enterica Serovar Typhimurium in Mice

A phosphotransacetylase (pta) mutant of Salmonella enterica serovar Typhimurium was attenuated in mice but survived normally in macrophages. Complementation of the pta mutation in trans restored virulence. An isocitrate lyase (aceA) mutant was virulent, so the inability to use acetate as a sole carb...

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Detalhes bibliográficos
Main Authors: Kim, Yang Re, Brinsmade, Shaun R., Yang, Zheng, Escalante-Semerena, Jorge, Fierer, Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418904/
https://ncbi.nlm.nih.gov/pubmed/16552088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.4.2498-2502.2006
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