CpG-Modified Plasmid DNA Encoding Flagellin Improves Immunogenicity and Provides Protection against Burkholderia pseudomallei Infection in BALB/c Mice

The plasmid DNA encoding the fliC gene of Burkholderia pseudomallei combined with CpG oligodeoxynucleotide (ODN) was injected intramuscularly into BALB/c mice, resulting in the increased production of certain humoral antibodies and flagellin-specific spleen cell clonal expansion. CpG ODN, as an immu...

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Detalhes bibliográficos
Main Authors: Chen, Yao-Shen, Hsiao, Yu-Shan, Lin, Hsi-Hsun, Liu, Yin, Chen, Ya-Lei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418635/
https://ncbi.nlm.nih.gov/pubmed/16495541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.3.1699-1705.2006
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