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Role of LIM Kinases in Normal and Psoriatic Human Epidermis
We present evidence that LIM kinases can control cell adhesion and compaction in human epidermis. LIMK2 is expressed in the epidermal basal layer and signals downstream of the GTPase Rac1 to promote extracellular matrix adhesion and inhibit terminal differentiation. Conversely, LIMK1 is expressed in...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Cell Biology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1415329/ https://ncbi.nlm.nih.gov/pubmed/16467374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-12-1173 |
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