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Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae

Mutations in RRP6 result in the accumulation of aberrant polyadenylated transcripts from small nucleolar RNA genes. We exploited this observation to search for novel noncoding RNA genes in the yeast genome. When RNA from rrp6Δ yeast is compared with wild-type on whole-genome microarrays, numerous in...

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Detalles Bibliográficos
Main Authors: Davis, Carrie Anne, Ares, Manuel
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413877/
https://ncbi.nlm.nih.gov/pubmed/16484372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507783103
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