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Ceramide mediates the rapid phase of febrile response to IL-1β
IL-1β was identified after a long search for the endogenous pyrogen. It acts by inducing synthesis of prostaglandin E(2), which mediates the late phase of IL-1β-induced fever. Here we show by radiotelemetry that the early phase of the fever response to IL-1β is mediated by ceramide. Hypothalamic app...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413811/ https://ncbi.nlm.nih.gov/pubmed/16477014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510960103 |
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