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ALADIN(I482S) causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome

Triple A syndrome is an autosomal recessive neuroendocrinological disease caused by mutations in a gene that encodes 546 amino acid residues. The encoded protein is the nucleoporin ALADIN, a component of nuclear pore complex (NPC). We identified a mutant ALADIN(I482S) that fails to target NPC and in...

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Main Authors: Hirano, Makito, Furiya, Yoshiko, Asai, Hirohide, Yasui, Akira, Ueno, Satoshi
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413683/
https://ncbi.nlm.nih.gov/pubmed/16467144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505598103
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