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ALADIN(I482S) causes selective failure of nuclear protein import and hypersensitivity to oxidative stress in triple A syndrome
Triple A syndrome is an autosomal recessive neuroendocrinological disease caused by mutations in a gene that encodes 546 amino acid residues. The encoded protein is the nucleoporin ALADIN, a component of nuclear pore complex (NPC). We identified a mutant ALADIN(I482S) that fails to target NPC and in...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413683/ https://ncbi.nlm.nih.gov/pubmed/16467144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505598103 |
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