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Insight into autoproteolytic activation from the structure of cephalosporin acylase: A protein with two proteolytic chemistries
Cephalosporin acylase (CA), a member of the N-terminal nucleophile hydrolase family, is activated through sequential primary and secondary autoproteolytic reactions with the release of a pro segment. We have determined crystal structures of four CA mutants. Two mutants are trapped after the primary...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413634/ https://ncbi.nlm.nih.gov/pubmed/16446446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507862103 |
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