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Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints
The inactivation of either subunit of the Ku70-Ku80 heterodimer, which functions in nonhomologous end-joining and telomere maintenance, generates severe defects such as sensitivity to DNA damage, telomere shortening, and increased gross chromosomal rearrangements (GCRs) that are frequently observed...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413618/ https://ncbi.nlm.nih.gov/pubmed/16446442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504063102 |
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