Mechanism of Reduced T-Cell Effector Functions and Class-Switched Antibody Responses to Herpes Simplex Virus Type 2 in the Absence of B7 Costimulation

T-cell costimulation molecules B7-1 and B7-2 play an important role in activation of T cells to cytolytic effector function and production of cytokines. Interaction with B7 also causes T cells to upregulate surface molecules, such as CD40L, that effectively stimulate antibody responses in conjunctio...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Thebeau, Lydia G., Morrison, Lynda A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141105/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12551980/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.4.2426-2435.2003
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