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A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli
We present evidence for a complex regulatory interplay between the initiation of DNA replication and deoxyribonucleotide synthesis. In Escherichia coli, the ATP-bound DnaA protein initiates chromosomal replication. Upon loading of the β-clamp subunit (DnaN) of the replicase, DnaA is inactivated as i...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1409723/ https://ncbi.nlm.nih.gov/pubmed/16482221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600990 |
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