A Live, Attenuated Dengue Virus Type 1 Vaccine Candidate with a 30-Nucleotide Deletion in the 3′ Untranslated Region Is Highly Attenuated and Immunogenic in Monkeys

The Δ30 deletion mutation, which was originally created in dengue virus type 4 (DEN4) by the removal of nucleotides 172 to 143 from the 3′ untranslated region (3′ UTR), was introduced into a homologous region of wild-type (wt) dengue virus type 1 (DEN1). The resulting virus, rDEN1Δ30, was attenuated...

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Bibliographische Detailangaben
Hauptverfasser: Whitehead, Stephen S., Falgout, Barry, Hanley, Kathryn A., Blaney, Jr., Joseph E., Markoff, Lewis, Murphy, Brian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2003
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC140839/
https://ncbi.nlm.nih.gov/pubmed/12502885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1653-1657.2003
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