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Negative Regulation of Mitotic Promoting Factor by the Checkpoint Kinase Chk1 in Simian Virus 40 Lytic Infection

Lytic infection of African green monkey kidney (CV-1) cells by simian virus 40 (SV40) is characterized by stimulation of DNA synthesis leading to bypass of mitosis and replication of cellular and viral DNA beyond a 4C DNA content. To define mechanisms underlying the absence of mitosis, the expressio...

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Detalles Bibliográficos
Main Authors: Okubo, Eiji, Lehman, John M., Friedrich, Thomas D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC140779/
https://ncbi.nlm.nih.gov/pubmed/12502843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1257-1267.2003
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