Proteasome Inhibition Results in TRAIL Sensitization of Primary Keratinocytes by Removing the Resistance-Mediating Block of Effector Caspase Maturation

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts potent cytotoxic activity against transformed keratinocytes, whereas primary keratinocytes are relatively resistant. In several cell types, inhibition of the proteasome sensitizes for TRAIL-induced apoptosis by interference with...

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Autors principals: Leverkus, Martin, Sprick, Martin R., Wachter, Tina, Mengling, Thilo, Baumann, Bernd, Serfling, Edgar, Bröcker, Eva-B., Goebeler, Matthias, Neumann, Manfred, Walczak, Henning
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC140698/
https://ncbi.nlm.nih.gov/pubmed/12529384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.777-790.2003
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