The Leucine Zipper Motif of the Drosophila AF10 Homologue Can Inhibit PRE-Mediated Repression: Implications for Leukemogenic Activity of Human MLL-AF10 Fusions

In a screen for Drosophila genes that interfere with transcriptional repression mediated by the Polycomb group of genes, we identified a dominant mutation affecting the Alhambra (Alh) gene, the fly homologue of the human AF10 gene. AF10 has been identified as a fusion partner of both MLL and CALM in...

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Detalhes bibliográficos
Main Authors: Perrin, Laurent, Bloyer, Sébastien, Ferraz, Conchita, Agrawal, Namita, Sinha, Pradip, Dura, Jean Maurice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140655/
https://ncbi.nlm.nih.gov/pubmed/12482966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.119-130.2003
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