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Heterologous Expression of Membrane and Soluble Proteins Derepresses GCN4 mRNA Translation in the Yeast Saccharomyces cerevisiae

This paper describes the first physiological response at the translational level towards heterologous protein production in Saccharomyces cerevisiae. In yeast, the phosphorylation of eukaryotic initiation factor 2α (eIF-2α) by Gcn2p protein kinase mediates derepression of GCN4 mRNA translation. Gcn4...

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Detaylı Bibliyografya
Asıl Yazarlar: Steffensen, Lotte, Pedersen, Per Amstrup
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1405899/
https://ncbi.nlm.nih.gov/pubmed/16467466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.5.2.248-261.2006
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