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mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity
Type II Human DNA Topoisomerases (topos II) play an essential role in DNA replication and transcription and are important targets for cancer chemotherapeutic drugs. Topoisomerase II causes transient double-strand breaks in DNA, forming a gate through which another double helix is passed, and acts as...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2006
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1405819/ https://ncbi.nlm.nih.gov/pubmed/16549872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl057 |
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