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Tolerance for mutations and chemical modifications in a siRNA

Short interfering RNA (siRNA), the active agent of RNA interference, shows promise of becoming a valuable tool in both basic and clinical research. We explore the tolerance to mutations and chemical modifications in various parts of the two 21-nt strands of a siRNA targeting the blood clotting initi...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Principais autores: Amarzguioui, Mohammed, Holen, Torgeir, Babaie, Eshrat, Prydz, Hans
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140512/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12527766/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg147
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