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Tolerance for mutations and chemical modifications in a siRNA

Short interfering RNA (siRNA), the active agent of RNA interference, shows promise of becoming a valuable tool in both basic and clinical research. We explore the tolerance to mutations and chemical modifications in various parts of the two 21-nt strands of a siRNA targeting the blood clotting initi...

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Détails bibliographiques
Auteurs principaux: Amarzguioui, Mohammed, Holen, Torgeir, Babaie, Eshrat, Prydz, Hans
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC140512/
https://ncbi.nlm.nih.gov/pubmed/12527766
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