Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

BACKGROUND: CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer mono...

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Main Authors: Pavoni, Emiliano, Flego, Michela, Dupuis, Maria Luisa, Barca, Stefano, Petronzelli, Fiorella, Anastasi, Anna Maria, D'Alessio, Valeria, Pelliccia, Angela, Vaccaro, Paola, Monteriù, Giorgia, Ascione, Alessandro, De Santis, Rita, Felici, Franco, Cianfriglia, Maurizio, Minenkova, Olga
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1402309/
https://ncbi.nlm.nih.gov/pubmed/16504122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-41
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