Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

Complete activation of signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Y701 and a conserved PMS(727)P sequence. S727 phosphorylation of STAT1 in interferon-γ (IFN-γ)-treated mouse fibroblasts occurred without a need for p38 mitogen-activated protein kinase...

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Detalhes bibliográficos
Main Authors: Kovarik, Pavel, Mangold, Monika, Ramsauer, Katrin, Heidari, Hamid, Steinborn, Ralf, Zotter, Angelika, Levy, David E., Müller, Mathias, Decker, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140204/
https://ncbi.nlm.nih.gov/pubmed/11226159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.1.91
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