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The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships.

1 A combined pharmacokinetic and pharmacodynamic model has been used to analyze the relationship between electrocardiographic (ECG) and systolic time intervals (STI) and changes in plasma concentration of quinidine after oral and i.v. doses in ten normal subjects. 2 The major effects of quinidine we...

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Autors principals: Holford, N H, Coates, P E, Guentert, T W, Riegelman, S, Sheiner, L B
Format: Artigo
Idioma:Inglês
Publicat: 1981
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1401584/
https://ncbi.nlm.nih.gov/pubmed/7213522
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