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POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis

We report that the multidomain protein POSH (plenty of SH3s) acts as a scaffold for the JNK pathway of neuronal death. This pathway consists of a sequential cascade involving activated Rac1/Cdc42, mixed-lineage kinases (MLKs), MAP kinase kinases (MKKs) 4 and 7, c-Jun N-terminal kinases (JNKs) and c-...

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Detalhes bibliográficos
Main Authors: Xu, Zhiheng, Kukekov, Nickolay V., Greene, Lloyd A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140096/
https://ncbi.nlm.nih.gov/pubmed/12514131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg021
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