Redundancy in Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) Signaling In Vivo: Mice with Inactivation of the Entire TNF/LT Locus versus Single-Knockout Mice

Homologous genes and gene products often have redundant physiological functions. Members of the tumor necrosis factor (TNF) family of cytokines can signal activation, proliferation, differentiation, costimulation, inhibition, or cell death, depending on the type and status of the target cell. TNF, l...

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Hauptverfasser: Kuprash, Dmitry V., Alimzhanov, Marat B., Tumanov, Alexei V., Grivennikov, Sergei I., Shakhov, Alexander N., Drutskaya, Ludmila N., Marino, Michael W., Turetskaya, Regina L., Anderson, Arthur O., Rajewsky, Klaus, Pfeffer, Klaus, Nedospasov, Sergei A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139867/
https://ncbi.nlm.nih.gov/pubmed/12446781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.24.8626-8634.2002
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