Multiple Developmental Defects Derived from Impaired Recruitment of ASC-2 to Nuclear Receptors in Mice: Implication for Posterior Lenticonus with Cataract

ASC-2, a recently isolated transcriptional coactivator molecule, stimulates transactivation by multiple transcription factors, including nuclear receptors. We generated a potent dominant negative fragment of ASC-2, encompassing the N-terminal LXXLL motif that binds a broad range of nuclear receptors...

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Detalhes bibliográficos
Main Authors: Kim, Seung-Whan, Cheong, Cheolho, Sohn, Young-Chang, Goo, Young-Hwa, Oh, Wan Je, Park, Jung Hwan, Joe, So Young, Kang, Hyen-Sam, Kim, Duk-Kyung, Kee, Changwon, Lee, Jae Woon, Lee, Han-Woong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139866/
https://ncbi.nlm.nih.gov/pubmed/12446761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.24.8409-8414.2002
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