Phosphorylation and Intramolecular Stabilization of the Ligand Binding Domain in the Nuclear Receptor Steroidogenic Factor 1

Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor with no known ligand. We showed previously that phosphorylation at serine 203 located N′-terminal to the ligand binding domain (LBD) enhanced cofactor recruitment, analogous to the ligand-mediated recruitment in ligand-dependent receptors....

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Bibliografski detalji
Glavni autori: Desclozeaux, Marion, Krylova, Irina N., Horn, Florence, Fletterick, Robert J., Ingraham, Holly A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Transcriptional Regulation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC139795/
https://ncbi.nlm.nih.gov/pubmed/12242296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7193-7203.2002
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