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Phosphorylation and Intramolecular Stabilization of the Ligand Binding Domain in the Nuclear Receptor Steroidogenic Factor 1

Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor with no known ligand. We showed previously that phosphorylation at serine 203 located N′-terminal to the ligand binding domain (LBD) enhanced cofactor recruitment, analogous to the ligand-mediated recruitment in ligand-dependent receptors....

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Udgivet i:Mol Cell Biol
Principais autores: Desclozeaux, Marion, Krylova, Irina N., Horn, Florence, Fletterick, Robert J., Ingraham, Holly A.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139795/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242296/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.20.7193-7203.2002
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