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PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

PIAS (protein inhibitor of activated STAT) proteins interact with and modulate the activities of various transcription factors. In this work, we demonstrate that PIAS proteins xα, xβ, 1, and 3 interact with the small ubiquitin-related modifier SUMO-1 and its E2 conjugase, Ubc9, and that PIAS protein...

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Udgivet i:Mol Cell Biol
Principais autores: Kotaja, Noora, Karvonen, Ulla, Jänne, Olli A., Palvimo, Jorma J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139781/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077349/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5222-5234.2002
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