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Chromatin Assembly Factor I Mutants Defective for PCNA Binding Require Asf1/Hir Proteins for Silencing

Chromatin assembly factor I (CAF-I) is a conserved histone H3/H4 deposition complex. Saccharomyces cerevisiae mutants lacking CAF-I subunit genes (CAC1 to CAC3) display reduced heterochromatic gene silencing. In a screen for silencing-impaired cac1 alleles, we isolated a mutation that reduced bindin...

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Udgivet i:Mol Cell Biol
Principais autores: Krawitz, Denise C., Kama, Tamar, Kaufman, Paul D.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139734/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756556/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.2.614-625.2002
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