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Point Mutations in HpuB Enable Gonococcal HpuA Deletion Mutants To Grow on Hemoglobin

Neisseria gonorrhoeae ordinarily requires both HpuA and HpuB to use hemoglobin (Hb) as a source of iron for growth. Deletion of HpuA resulted in reduced Hb binding and failure of growth on Hb. We identified rare Hb-utilizing colonies (Hb(+)) from an hpuA deletion mutant of FA1090, which fell into tw...

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Detalhes bibliográficos
Main Authors: Chen, Ching-Ju, Mclean, Dalton, Thomas, Christopher E., Anderson, James E., Sparling, P. Frederick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139576/
https://ncbi.nlm.nih.gov/pubmed/11751818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.184.2.420-426.2002
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