Global Suppression of the Host Antiviral Response by Ebola- and Marburgviruses: Increased Antagonism of the Type I Interferon Response Is Associated with Enhanced Virulence

We studied the effect of filovirus infection on host cell gene expression by characterizing the regulation of gene expression responses in human liver cells infected with Zaire Ebolavirus (ZEBOV), Reston Ebolavirus (REBOV), and Marburgvirus (MARV), using transcriptional profiling and bioinformatics....

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Bibliographic Details
Main Authors: Kash, John C., Mühlberger, Elke, Carter, Victoria, Grosch, Melanie, Perwitasari, Olivia, Proll, Sean C., Thomas, Matthew J., Weber, Friedemann, Klenk, Hans-Dieter, Katze, Michael G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395418/
https://ncbi.nlm.nih.gov/pubmed/16501110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.6.3009-3020.2006
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