A Single Intranasal Inoculation with a Paramyxovirus-Vectored Vaccine Protects Guinea Pigs against a Lethal-Dose Ebola Virus Challenge

To determine whether intranasal inoculation with a paramyxovirus-vectored vaccine can induce protective immunity against Ebola virus (EV), recombinant human parainfluenza virus type 3 (HPIV3) was modified to express either the EV structural glycoprotein (GP) by itself (HPIV3/EboGP) or together with...

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Detalhes bibliográficos
Main Authors: Bukreyev, Alexander, Yang, Lijuan, Zaki, Sherif R., Shieh, Wun-Ju, Rollin, Pierre E., Murphy, Brian R., Collins, Peter L., Sanchez, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395378/
https://ncbi.nlm.nih.gov/pubmed/16474134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.5.2267-2279.2006
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