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Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor

Rifampicin, an important drug in the treatment of tuberculosis, is used extensively despite its broad effects on drug-drug interactions, creating serious problems. The clinical importance of such interactions includes autoinduction leading to suboptimal or failed treatment. The concomitantly adminis...

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Détails bibliographiques
Auteurs principaux: Chen, Jiezhong, Raymond, Kenneth
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1395332/
https://ncbi.nlm.nih.gov/pubmed/16480505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-0711-5-3
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