Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats

Experiments in the GT1 gonadotropin-releasing hormone (GnRH) cell line have shown that the cAMP signaling pathway plays a central role in regulating the excitability of the cells. Lowering cAMP levels by expressing the constitutively active cAMP-specific phosphodiesterase PDE4D1 in GT1 cells inhibit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Paruthiyil, Sreenivasan, Majdoubi, Mohammed El, Conti, Marco, Weiner, Richard I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139291/
https://ncbi.nlm.nih.gov/pubmed/12482943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012678999
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge