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Engineered calmodulins reveal the unexpected eminence of Ca(2+) channel inactivation in controlling heart excitation
Engineered calmodulins (CaMs), rendered Ca(2+)-insensitive by mutations, function as dominant negatives in heterologous systems, and have revealed mechanisms of ion channel modulation by Ca(2+)/CaM. The use of these CaMs in native mammalian cells now emerges as a strategy to unmask the biology of su...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139290/ https://ncbi.nlm.nih.gov/pubmed/12486220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262372999 |
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