A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules

Class II MHC molecules undergo conformational changes on shifts of the pH. As a consequence, low-affinity peptides tightly bound at pH 7.0 can be released at pH 5.0. The imidazole group of histidine is the only amino acid side chain affected within this range. At pH 5.0 the group is positively charg...

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Bibliographic Details
Main Authors: Rötzschke, Olaf, Lau, Julie M., Hofstätter, Maria, Falk, Kirsten, Strominger, Jack L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC139249/
https://ncbi.nlm.nih.gov/pubmed/12471156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212643999
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