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A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules
Class II MHC molecules undergo conformational changes on shifts of the pH. As a consequence, low-affinity peptides tightly bound at pH 7.0 can be released at pH 5.0. The imidazole group of histidine is the only amino acid side chain affected within this range. At pH 5.0 the group is positively charg...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139249/ https://ncbi.nlm.nih.gov/pubmed/12471156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212643999 |
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