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Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts

We investigated the effect of actin filament barbed end uncapping on Arp2/3 complex function both in vivo and in vitro. Arp2/3 complex redistributes rapidly and uniformly to the lamellar edge of activated wild-type platelets and fibroblasts but clusters in marginal actin filament clumps in gelsolin-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Falet, Hervé, Hoffmeister, Karin M., Neujahr, Ralph, Italiano, Joseph E., Stossel, Thomas P., Southwick, Frederick S., Hartwig, John H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2002
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC139221/
https://ncbi.nlm.nih.gov/pubmed/12464680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222652499
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