In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation

Trichostatin A (TSA) inhibits all histone deacetylases (HDACs) of both class I and II, whereas trapoxin (TPX) cannot inhibit HDAC6, a cytoplasmic member of class II HDACs. We took advantage of this differential sensitivity of HDAC6 to TSA and TPX to identify its substrates. Using this approach, α-tu...

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Hauptverfasser: Matsuyama, Akihisa, Shimazu, Tadahiro, Sumida, Yuko, Saito, Akiko, Yoshimatsu, Yasuhiro, Seigneurin-Berny, Daphné, Osada, Hiroyuki, Komatsu, Yasuhiko, Nishino, Norikazu, Khochbin, Saadi, Horinouchi, Sueharu, Yoshida, Minoru
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2002
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC139102/
https://ncbi.nlm.nih.gov/pubmed/12486003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf682
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