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Stereochemistry and Position-Dependent Effects of Carcinogens on TATA/TBP Binding
The TATA-box binding protein (TBP) is required by eukaryotic RNA polymerases to bind to the TATA box, an eight-basepair DNA promoter element, to initiate transcription. Carcinogen adducts that bind to the TATA box can hamper this important process. Benzo[a]pyrene (BP) is a representative chemical ca...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1386768/ https://ncbi.nlm.nih.gov/pubmed/16387764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.074344 |
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