Effect of the removal of individual antiepileptic drugs on antipyrine kinetics, in patients taking polytherapy.

1. Antipyrine (AP) clearance, half-life and volume of distribution were determined in 52 patients, taking one or more antiepileptic drug (AED), before and 4 weeks after the complete removal of phenytoin (PHT, n = 20), carbamazepine (CBZ, n = 15) and sodium valproate (VPA, n = 17). 2. PHT removal was...

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Autori principali: Patsalos, P N, Duncan, J S, Shorvon, S D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1988
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386536/
https://ncbi.nlm.nih.gov/pubmed/3179165
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