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A Specific Structural Requirement for Ergosterol in Long-chain Fatty Acid Synthesis Mutants Important for Maintaining Raft Domains in Yeast

Fungal sphingolipids contain ceramide with a very-long-chain fatty acid (C26). To investigate the physiological significance of the C26-substitution on this lipid, we performed a screen for mutants that are synthetically lethal with ELO3. Elo3p is a component of the ER-associated fatty acid elongase...

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Detalhes bibliográficos
Main Authors: Eisenkolb, Marlis, Zenzmaier, Christoph, Leitner, Erich, Schneiter, Roger
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC138643/
https://ncbi.nlm.nih.gov/pubmed/12475962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-02-0116
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