Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and prevents conformational changes required for membrane fusion. HR1 appears to become accessible to T-20 after Env bi...

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Detalhes bibliográficos
Main Authors: Reeves, Jacqueline D., Gallo, Stephen A., Ahmad, Navid, Miamidian, John L., Harvey, Phoebe E., Sharron, Matthew, Pöhlmann, Stefan, Sfakianos, Jeffrey N., Derdeyn, Cynthia A., Blumenthal, Robert, Hunter, Eric, Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC138597/
https://ncbi.nlm.nih.gov/pubmed/12444251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252469399
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