Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and prevents conformational changes required for membrane fusion. HR1 appears to become accessible to T-20 after Env bi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Reeves, Jacqueline D., Gallo, Stephen A., Ahmad, Navid, Miamidian, John L., Harvey, Phoebe E., Sharron, Matthew, Pöhlmann, Stefan, Sfakianos, Jeffrey N., Derdeyn, Cynthia A., Blumenthal, Robert, Hunter, Eric, Doms, Robert W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2002
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC138597/
https://ncbi.nlm.nih.gov/pubmed/12444251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252469399
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak