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Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and prevents conformational changes required for membrane fusion. HR1 appears to become accessible to T-20 after Env bi...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Reeves, Jacqueline D., Gallo, Stephen A., Ahmad, Navid, Miamidian, John L., Harvey, Phoebe E., Sharron, Matthew, Pöhlmann, Stefan, Sfakianos, Jeffrey N., Derdeyn, Cynthia A., Blumenthal, Robert, Hunter, Eric, Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC138597/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12444251/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.252469399
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